Saturday, December 31, 2011

Download Facebook Messenger for Windows

Download Facebook Messenger for Windows as a standalone desktop app with which you can use without visiting the website facebook.com. The new Facebook messenger is a trial app and you can download and try it right now

Download Facebook Messenger

Facebook MessengerAs you surf the web, you can use the Facebook Messenger for Facebook Chat with your Facebook friends, see the latest updates from your friends in ticker and get quick Facebook updates and notifications.

After installing Facebook?Messenger, you can easily do Facebook login and logout by right-clicking the Facebook icon in Windows system tray.?Once you open the app, the app is undocked by default so that you can move it around your computer screen, but you can dock the app and fix it on the screen also.

Choose the ?Keep me logged in? option and Messenger will keep you logged in to Facebook even after you close your browser or navigate away from Facebook. Remember, choosing?Exit?will close the app but still keep you logged into Facebook; therefore choose?Log out to completely logout of both the Messenger app and facebook.com, especially if your computer has multiple users or public use.

facebook logout

Facebook Messenger has some limitations ? unlike the website login, you cannot perform Facebook?Chat with multiple friends, video calling, limit chat availability and edit settings as of now. You will need to go to your browser and login for that.

Download Facebook Messenger?(.exe file).?This will download a?small .exe file, click that and it will download and install Facebook Messenger. The app will automatically install updates in future.?Since this is a trial app, be ready to?expect outages and periods of instability at times. System requirement says you need ?Windows 7 (but I was easily able to download on my Windows Vista). You can uninstall Facebook Messenger anytime from Windows Control Panel.

Source: http://www.quickonlinetips.com/archives/2011/12/download-facebook-messenger-for-windows/

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LG to Show Off 84-Inch ?Ultra Definition? TV at CES

Apparently, a 55-inch OLED television isn't wowing enough. So, in addition to the TV we reported on Tuesday, LG will also be unveiling at CES what it describes as the world's largest 3-D "Ultra Definition" television -- an 84-inch, 3840x2160 resolution 3-D display.

Source: http://feedproxy.google.com/~r/GearFactor/~3/U4xm6SKipB4/

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Iowa ad war: late starting but nasty (AP)

DES MOINES, Iowa ? At least $12.5 million and counting has blanketed the airwaves ahead of next Tuesday's Republican presidential caucuses, with hard-hitting commercials awash in ghoulish images and startling claims. Most are coming from a proliferation of new independent groups aligned with the candidates.

To hear the ads tell it, Newt Gingrich is a "serial hypocrite," Rick Perry "double dips" as governor and the "liberal Republican establishment" is plotting to anoint Mitt Romney as the party's presidential nominee. The attacks, the bulk of the commercials on the air, reflected the volatile state of the race five days before the first votes of the GOP presidential nominating contest.

After a slow start, the ads in Iowa are coming on fast and furious.

On Thursday alone, at least five new commercials were rolled out, including one by Perry castigating his rivals as Washington insiders and saying: "The fox guarding the henhouse is like asking a congressman to fix Washington: bad idea." An outside group aligned with Romney, Restore Our Future, rolled out a new spot that criticizes Gingrich and asks: "Haven't we had enough mistakes?"

In the final days of the Iowa campaign, most of the ads are deeply negative, thanks in large part to the proliferation of outside groups, known as super PACs, that are doing the dirty work for candidates they support. Gingrich has been the biggest target, withering under attacks from Ron Paul and Rick Perry's campaign as well as from several outside groups like the one aligned with Romney. Polls show that Gingrich's standing in Iowa has slid accordingly.

"I call it ad wars whack-a-mole ? this endless attacking in all directions, trying to slam down anyone who is surging to the top," said David Perlmutter, a University of Iowa journalism professor who studies political communication. "This is the most negative I've ever seen it. The ads are so blatantly negative I would have told you 10 years ago this would never fly in Iowa."

It's a different landscape in the campaign advertising world than four years ago when Barack Obama won Iowa's Democratic caucuses and Mike Huckabee carried the Republican side. Social media has intensified the advertising binge, with many spots debuting on TV but also going viral across the web at almost no cost to the campaigns that sponsor them. Candidates are making heavy use of online advertising to target voters based on location and other demographic information.

Campaigns are also producing video specifically for the YouTube audience, like a new 90-second Romney video excerpting a speech Obama delivered in Iowa days before winning the Democratic caucuses in 2008.

"Well, Mr. President, you've had your moment ... this is our time," Romney says in the spot.

On Thursday, Jon Huntsman's campaign ? which can't afford to put commercials on TV and is competing only in New Hampshire ? hit at Paul in a new web video that highlights comments about race and gays in newsletters Paul used to put out. The ad asks: "Can New Hampshire voters really trust Ron Paul?'"

But nothing has altered the environment more than super PACs, which are facing their first test in a presidential campaign since a Supreme Court decision two years ago eased restrictions on campaign spending by corporations, unions and individuals.

Much of $12.5 million spent to date in Iowa, a figure confirmed by ad tracking firms, outside groups and the GOP campaigns, has been spent in just the past few weeks, much of it paying for negative ads.

The pro-Romney super PAC, Restore Our Future, has been by far the most influential in Iowa, helping to bolster the former Massachusetts governor's position in the state he lost in 2008, crippling that campaign.

The group formed by Romney allies has spent at least $2.7 million in the state. The vast majority has been used to trash Gingrich, the former House speaker whose sudden surge in the polls earlier this month has been summarily halted in recent days. In ad after ad, Romney's allies have berated Gingrich for ethical "baggage," accepting $1.6 million in consulting fees from federal mortgage giant Freddie Mac and pledging to tackle climate change in an ad with House Democratic Leader Nancy Pelosi.

Another new ad from the group goes after both Gingrich and Perry for being "liberal on immigration."

Perry, the Texas governor, has defended his state's policy of allowing the children of illegal immigrants to pay in-state tuition rates at public universities, while Gingrich has spoken out against deporting those who have lived in the U.S. for many years without permission to be in the country.

The ad also chides Perry for taking advantage of a loophole in state law that allows him to supplement his governor's salary with his $90,000 annual pension, even as Perry has used his own ads to rail against congressional salaries.

Romney has stepped up his advertising presence in Iowa, driving a largely positive message while his allies have made it easy for him to avoid attacking his Republican rivals.

"In the campaign to come, the American ideals of economic freedom and opportunity need a clear and unapologetic defense. And I intend to make it because I have lived it," Romney says in a new uplifting 60-second commercial he began airing Thursday.

Gingrich, for his part, has railed against the Romney allies' ad blitz but has refused to respond in kind. A pro-Gingrich super PAC has begun fighting back, running ads in Iowa claiming the Republican establishment is "attacking him with falsehoods."

The ad warns: "Don't let the liberal Republican establishment pick our candidate."

But the assist from the pro-Gingrich group Winning Our Future may be too little, too late. A new CNN-Time poll found Gingrich now in fourth place in Iowa, behind Romney, Paul and Rick Santorum.

Other Republican hopefuls have super PACs that support them, including Perry and Santorum. The former Pennsylvania senator has run no ads of his own but has seen his position in Iowa strengthen in recent days in part by $327,000 in ad spending from a super PAC called the Red White and Blue Fund.

Our Destiny, a super PAC backing Huntsman, has run ads in New Hampshire for the former Utah governor. Huntsman is skipping the Iowa caucuses to focus on New Hampshire, which holds the nation's first primary on Jan. 10.

Perry has run the most campaign ads in Iowa, spending at least $3.9 million so far. His ads have offered a smattering of sometimes conflicting messages ? promoting his conservative Christian faith in one to calling for a part-time Congress in another.

"I'm an outsider who will overhaul Washington," Perry says in his latest ad, while pledging anew to end "Obama's war on religion."

Make Us Great Again, a pro-Perry super PAC, has also been on the air for weeks in Iowa.

The heavy spending hasn't seemed to help Perry much ? polls have consistently shown him trailing in the state, though he has gained some ground.

Paul has also been on the air for months and has not been shy about hitting his opponents. His latest ad, titled "Washington Machine," hits Gingrich as a "serial hypocrite" and Romney as a "flip flopper."

Cash strapped and struggling in polls, Michele Bachmann will run TV commercials a day before the caucuses. Her campaign has run radio ads and she's sought free media on a bus tour through Iowa's 99 counties.

___

Associated Press writers Brian Bakst in Iowa and Jack Gillum in Washington contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/politics/*http%3A//news.yahoo.com/s/ap/20111230/ap_on_el_pr/us_campaign_iowa_ad_crush

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A's trade closer Bailey, OF Sweeney to Red Sox (AP)

BOSTON ? For Andrew Bailey, coming in from the bullpen at Fenway Park is a special feeling.

He'll experience that a lot more next season.

New manager Bobby Valentine found his new man for the back end of the Boston bullpen on Wednesday when the Red Sox obtained the All-Star closer and outfielder Ryan Sweeney from the Oakland Athletics for outfielder Josh Reddick, infield prospect Miles Head and minor league pitcher Raul Alcantara.

In the deal, first reported by ESPN, Bailey gives the Red Sox a reliable ninth-inning guy to replace the departed Jonathan Papelbon, who signed a $50 million, four-year contract as a free agent with the Philadelphia Phillies in November.

The 27-year-old Bailey has three saves in four appearances at Fenway Park in his three major-league seasons.

"The one that sticks out the most was my first save opportunity this year was against the Red Sox," Bailey said in a conference call. "I actually blew that save. From what I remember, there's nothing like the atmosphere of running into the game from the bullpen at Fenway Park."

A New Jersey native and offseason resident of Connecticut, Bailey is excited about coming back east.

He already knows Valentine, who lives in Stamford, Conn., and hosted several events for the pediatric cancer foundation of Bailey and former teammate Craig Breslow.

"Bobby and I are good friends," Bailey said. "It just kind of helps knowing someone going in."

Bailey ? the 2009 AL Rookie of the Year, who made the All-Star team that season and again in 2010 ? had been the subject of trade talk this offseason.

The right-hander went 0-4 with a 3.24 ERA and 24 saves in 41 2-3 innings and 42 appearances this year. He spent time on the disabled list for the second straight season, pitching for the first time in 2011 on May 29 after being sidelined with a strained right forearm.

"I'm feeling good," he said. "This is my first healthy offseason I've had since I've been in the big leagues."

In his career, he is 7-10 with a 2.07 ERA and 75 saves in 84 opportunities. In 2010, Oakland led the AL in ERA (3.56) and shutouts (17) while holding opponents to a .245 batting average.

Bailey becomes the fourth key pitcher traded this month for the rebuilding A's, who dealt starter Trevor Cahill and reliever Breslow to the Arizona Diamondbacks on Dec. 9 and then sent left-handed starter Gio Gonzalez to Washington last week.

Still left in Oakland's depleted rotation are Dallas Braden, Brett Anderson and Brandon McCarthy.

Braden, who pitched a perfect game on May 9, 2010, received a $3.35 million, one-year contract Dec. 13. But he made only three starts last season before being sidelined by a shoulder injury that required surgery.

"That organization is heading down a different road where they're trying to get younger and build for a future in San Jose," Bailey said.

Oakland general manager Billy Beane is retooling his roster for the future in hopes of the franchise getting the go ahead to build a new ballpark some 40 miles south in San Jose despite the San Francisco Giants owning the territorial rights to technology-rich Santa Clara County.

Beane and owner Lew Wolff have said they expect to hear soon from Commissioner Bud Selig, and Beane said the unsettled stadium situation would affect him being able to sign his own and other free agents this winter. He has gone the trade route yet again, a common practice for the low-budget franchise that has watched its superstars leave for big money elsewhere over the past decade.

The A's (74-88) haven't posted a winning record or earned a playoff berth since being swept in the 2006 AL championship series by Detroit.

The Red Sox missed the playoffs the past two years, but won the World Series in 2004 and 2007.

"I think every kid playing T-ball out there strives to pitch in the postseason and meaningful games in September and, ultimately, the World Series," Bailey said. "So I'm going to welcome that with open arms."

On Dec. 14, Boston traded for Houston closer Mark Melancon, who had 20 saves last year in 71 relief outings but may be a setup man for Bailey.

"We believe both are fully capable of (closing)," Red Sox general manager Ben Cherington said. "Bailey's been doing it for a little bit longer so perhaps he goes in with the leg up."

Sweeney is in the mix for Boston's right field job now that J.D. Drew is a free agent. He's an outstanding fielder who can play all three spots. In six seasons, he has a .283 batting average after hitting .265 with one homer and 25 RBIs in 264 at bats last season.

Reddick, who began last season at Triple-A Pawtucket before being promoted in late May, will look to fill a big void in Oakland's open outfield.

The 24-year-old Reddick batted .280 with seven homers and 28 RBIs in 87 games for Boston in 2011. He can play any outfield spot and likely will get immediate action for the A's, who already lost outfielders David DeJesus and Josh Willingham in free agency. Center fielder Coco Crisp isn't expected to return either.

At last summer's trade deadline, the A's and Red Sox were near completion on a deal that would have sent Oakland right-hander Rich Harden to Boston for Triple-A first baseman Lars Anderson, but it fell through late because of Harden's lengthy list of injury issues.

Former Red Sox pitching coach Curt Young returned to the A's this offseason to work under manager Bob Melvin.

Head, a first baseman, batted .299 with 22 home runs and 82 RBIs in 129 games with the Red Sox two Single-A affiliates, at Greenville and Salem.

The right-handed Alcantara, 19, combined for a 1-4 record and a 2.20 ERA in 13 starts with Single-A Lowell and the Red Sox affiliate in the Gulf Coast League. He struck out 50 and walked just 12 while holding opponents to a .208 batting average.

___

AP Baseball Writer Janie McCauley contributed to this story.

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/ap/20111229/ap_on_sp_ba_ne/bba_red_sox_athletics_trade

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Thursday, December 29, 2011

US university offers MA in entrepreneurial journalism

US university offers MA in entrepreneurial journalism | Media | guardian.co.uk "); jQ('a.report-abuse:not(.no-abuse-popup)').live('click', function(ev) { ev.preventDefault(); loading_box.dialog({ title: "Abuse report", draggable: false, modal: true, width: 400, minHeight: 320, resizable: false, beforeclose: function(event, ui) { var readOnly = jQ('.report-abuse-ajax-readonly').length; if(readOnly == 1) return true; var reason = jQ('.report-abuse-ajax-form textarea#id_reason').val(); var thanksPage = jQ('.report-form-loading p[data-abuse-report-accepted-for-comment]').length; if (thanksPage == 0) { thanksPage = jQ('.report-form-loading p[data-abuse-report-accepted-for-profile]').length; } if(thanksPage == 0) { if(reason == 0) { return true; } else { return confirm("Closing this window without pressing \"Report\" will result in your words being lost. Are you sure?"); } } else { return true; } }, close: function(ev, ui) { loading_box.remove(); } }); abuse_report_url = this.href.replace('report-abuse', 'report-abuse-ajax'); abuse_report_url = fix_domain_for_careers(abuse_report_url); jQ.ajax({ url: abuse_report_url, success: function(data){ loading_box.html(data); } }); }); jQ('body').delegate('.report-abuse-ajax-form form', 'submit', function(ev) { ev.preventDefault(); var form = jQ(this); var url = fix_domain_for_careers(form.attr('action')); jQ.post(url, form.serialize(), function(html) { form.parents('.ui-dialog-content').html(html); // Has the abuse report been accepted? var el = jQ(html); var comment_id = el.attr('data-abuse-report-accepted-for-comment'); var profile_id = el.attr('data-abuse-report-accepted-for-profile'); if (comment_id) { jQ('ul#comment-' + comment_id).find('li.abuse-report').remove(); } else if (profile_id) { jQ('p.report-abuse').remove(); } var is_successful_submission = (comment_id || profile_id); if (is_successful_submission) { if(guardian.r2.omniture.isAvailable()) { // track with omniture s.linkTrackVars = 'events,eVar37'; s.linkTrackEvents = 'event37'; s.eVar37 = 'Comment:Report Abuse'; s.events = 'event37'; s.tl(true, 'o', 'Comment report abuse'); } window.setTimeout(function() { loading_box.dialog("close"); }, 3000); } }); }); //make sure submit button is enabled onReady. jQ('#newcommenting-form input[type=submit]' ).removeAttr('disabled'); var newFormURL = window.location.protocol + '//' + window.location.host + window.location.pathname + '?#post-area'; jQ('div#login-container form.post-your-comments').attr('action', newFormURL); jQ('div#signup-container input').click(function(){ urlStack.clearUrlStack(); urlStack.pushUrlOntoStack(newFormURL); document.location = 'http://users.guardian.co.uk/signup/tr/1,,-720,00.html'; }); jQ('.recomended').show(); jQ('#newcommenting-form').submit(function(){ jQ('input[type=submit]', this).attr('disabled', 'disabled'); }); }); //end jQ ready function openAbuseBox(commentId) { jQ("#abuse-report-comment-id").val(commentId); var loading_box = jQ('

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'); loading_box.dialog({ title:"Abuse report", draggable: false, modal:true, width:400, minHeight:320, resizable: false, beforeclose: function(event, ui) { var reason = jQ('textarea#id_reason').val(); if (reason != "") { return confirm("Closing this window without pressing \"Report\" will result in your words being lost. Are you sure?"); } else { return true; } } }); } function recommendComment(commentId) { var post_url = "http://www.guardian.co.uk/discussion/handlers/recommendComment"; post_url = fix_domain_for_careers(post_url); jQ.post(post_url, { comment_id: commentId }, function(data) { if (data == "OK") { var span = jQ("#recommended-count-" + commentId); span.prev('a').contents().unwrap(); span.text(parseInt(span.text(), 10)+1); } else { var span = jQ("#recommended-count-" + commentId); span.prev('a').contents().unwrap(); } }); }

Gov't to pay family $17.8M for military jet crash (AP)

SAN DIEGO ? A federal judge on Wednesday ordered the U.S. government to pay $17.8 million to a family that lost four members when a Marine Corps fighter jet crashed into their San Diego home in 2008.

U.S. District Judge Jeffrey Miller's ruling came after a nonjury trial between the Department of Justice and the family, who sought $56 million for emotional and monetary loss.

Don Yoon lost his 36-year-old wife, Youngmi Lee Yoon; his 15-month-old daughter, Grace; his 2-month-old daughter, Rachel; and his 59-year-old mother-in-law, Seokim Kim Lee, who was visiting from Korea to help her eldest daughter take care of their children.

Yoon said in a statement that Miller's ruling was "thoughtful, reasoned and just." Yoon broke down crying throughout his testimony, which came three years to the day when he buried his wife and baby girls in the same casket. He told the judge he only looks forward to the day when he can join them.

"Our family is relieved this part of the process is over, but no sum of money will ever make up for the loss of our loved ones," he said.

The Marine Corps has said the plane suffered a mechanical failure but a series of bad decisions led the pilot ? a student ? to bypass a potentially safe landing at a coastal Navy base after his engine failed on Dec. 8, 2008. The pilot ejected and told investigators he screamed in horror as he watched the jet plow into the neighborhood, incinerating two homes.

The case was unique in that the government admitted liability but disputed how much should be paid to Yoon and his extended family. Government lawyers had put economic losses at about $1 million but left it up to Miller to decide how much should be paid for the loss of love and companionship.

Department of Justice officials declined to comment Wednesday.

During the trial, government attorneys offered their condolences to the family but questioned how much they depended on each other. The law does not allow victims to be compensated for grief, suffering or punitive damages.

The judge said the deaths of the two girls deprived Yoon of "the comfort, companionship, society and love a young child is capable of providing to a new parent and, then, in later life. By all accounts, the Yoon girls would have been raised with traditional cultural and family values emphasizing love and devotion to parents and family."

He ordered Yoon to be awarded about $9.6 million, and his father-in-law, Sanghyun Lee, to be given about $3.7 million. Miller said $1.5 million should go to each of Lee's three adult children for the loss of their mother, Seokim Kim Lee.

In his written ruling, Miller called Seokim Kim Lee an "extraordinary woman whose profound and loving influence greatly molded, directly or indirectly, virtually every plaintiff in this case," after hearing the testimonies of her husband and children, who flew in from Korea to testify.

"And it's that remarkable influence which informs and helps to measure what fair and reasonable compensation should be awarded in this case," Miller wrote.

During the trial, the family's attorney, Brian Panish, showed photographs and videos depicting a close-knit farming family whose lives were shattered on two continents by the crash. Youngmi Lee came to the United States in 2004 to marry Yoon.

Yoon said he harbors no ill will toward the Marine pilot "who did everything he could to prevent this tragedy," but added that his family believes "that misguided attempts by the military to save money and cut costs" contributed to the crash.

"If the cost of paying fair compensation as ordered by this court will be factored into the daily decisions by our military in its operations that affect both military and civilian safety," other families may be saved, the family's statement said.

The military disciplined 13 members of the Marines and the Navy for the errors.

Source: http://us.rd.yahoo.com/dailynews/rss/usmilitary/*http%3A//news.yahoo.com/s/ap/20111228/ap_on_re_us/us_military_jet_crash

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Wednesday, December 28, 2011

More Schooling Might Raise IQ (HealthDay)

MONDAY, Dec. 26 (HealthDay News) -- Children who have more schooling may see their IQ improve, Norwegian researchers have found.

Although time spent in school has been linked with IQ, earlier studies did not rule out the possibility that people with higher IQs might simply be likelier to get more education than others, the researchers noted.

Now, however, "there is good evidence to support the notion that schooling does make you 'smarter' in some general relevant way as measured by IQ tests," said study author Taryn Galloway, a researcher at Statistics Norway in Oslo.

Findings from the large-scale study appear in this week's online edition of the Proceedings of the National Academy of Sciences.

IQ, or intelligence quotient, is a widely accepted measure of intelligence. The IQ score comes from several combined, standardized tests.

In 1955, Norway began extending compulsory middle school education by two years. Galloway and her colleague Christian Brinch, from the department of economics at the University of Oslo, analyzed how this additional schooling might affect IQ.

Using data on men born between 1950 and 1958, the researchers looked at the level of schooling by age 30. They also looked at IQ scores of the men when they were 19.

"The size of the effect was quite large," she said. Comparing IQ scores before and after the education reform, the average increased by 0.6 points, which correlated with an increase in IQ of 3.7 points for an addition year of schooling, Galloway said.

"We are only able to study men, because we use data on IQ from the Norwegian military's draft assessment, which basically all men undergo around the age of 19. Women are not included in the draft," she explained.

Education has lasting effects on cognitive skills, such as those broadly measured by IQ tests, Galloway said.

"Cognitive skills are, in turn, related to a large range of social and economic outcomes. A large part of the relevance of the study derives from the fact that there has been some controversy related to the question of whether education has an independent effect on IQ or whether people with higher IQs simply choose, or are better able, to attain higher levels of education," Galloway said.

By looking at a reform which increased mandatory schooling and prevented people from dropping out of school after the 7th grade, it is fairly certain that the effects seen are an effect of schooling on IQ, not vice versa, she explained.

"One subtle point of our findings is that we use IQ measures at roughly age 19, which is three to four years after the additional education generally was received. Thus, we are not simply picking up a short-lived effect that peters out shortly after people leave school," Galloway said.

The findings suggest that education as late as the middle teenage years may have a sizeable effect on IQ, but do not challenge the well-documented importance of early childhood experiences on cognitive development, according to the authors.

Robert Sternberg, a professor of psychology and provost at Oklahoma State University in Stillwater, said that "these results -- that schooling has a substantial effect on IQ -- replicate those of other, perhaps not quite as well-controlled, studies."

"I am aware of no serious studies that show the opposite result," he added.

He said the results are also consistent with the huge literature on the so-called Flynn effect showing that IQs are modifiable across as well as within generations and have been rising since the beginning of the 20th century.

"The results of this study are problematical for the chorus of psychologists and educators still locked in century-old thinking that IQ is genetic, stable and non-modifiable," Sternberg said. "As, for these individuals, the belief in the stability of IQ is more a matter of religious faith than of scientific inference, I doubt they will be persuaded."

More information

For more about IQ, visit the U.S. National Library of Medicine.

Source: http://us.rd.yahoo.com/dailynews/rss/parenting/*http%3A//news.yahoo.com/s/hsn/20111228/hl_hsn/moreschoolingmightraiseiq

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Looking for partners for interesting role plays

Hey there,

I'm Akira and I've been role playing for a little more two years now. I'm looking for a few people to start role playing with. I'm usually good at coming up with ideas but like having someone to bump those ideas off of and forming a greater role play with; Like a snowball. :D I'm pretty laid back, at least I like to think so, but I like planning so everyone is on the same page. I'm a little shy so I love it when people speak their minds. :3
I usually write four paragraphs and up. I've had up to eight characters before but prefer around four. I certainly don't mind groups, in fact, I really like them since that means even more people to throw ideas in and make it unique. I usually have male characters but may throw a female in there time to time. I'm fine with pretty much any gender/type relationship.
I am a high school student, currently on break, so there is a good chunk of the day I can't reply but will once I get home. Also, my cat likes to try to type. ^.^;

Role plays I'm interested in

    Asylum - about to have one going but willing to start another
    Horror - gore, gore, death, torture, gore. X3
    Fantasy - Modern, Dark, Medieval, etc
    Sci-fi - Like 'Mass Effect' and such
    Romance
    Realism
    Music
    Mythological
    Dante's Inferno
    MMORPG based - taking part in both 'real life' and in the game.
    Fandoms - There is a lot so just ask :3

There is a lot more I'd be willing to do but those are just my top few. If you have any ideas and want to throw them my way feel free. I'm open to most ideas.

Here's an idea I had:

Two males in their early twenties enter the life of prostitution. After a few years of working, one gets tired, numbs, and sick of the lifestyle. Something snaps in him and he begins killing females within a certain age group.

    1. The other male could go along with it and help him in murdering many women

    2. It could be unknown to the other male and they remain friends until he finds out

    3. The other male could find out early on and try to get him to stop

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/LEs4myMGXe0/viewtopic.php

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Tuesday, December 27, 2011

Yet another ?levels of personal finance? ? Grumpy rumblings of the ...

JD talks about the stages of personal finance:
1. learning the basics
2. practicing the basics
3. what next?
4. financial independence

A lot of folks follow these stages with step 0:? having lots of consumer debt, step 1 learning that they can get out of debt, step 2 actually getting out of debt, step 3 realizing they can do things like save for like travel (because in steps 1-3 they started disliking stuff), and finally step 4 being able to quit the job they hate and become full-time bloggers (etc.)

Some of us started out not only naturally frugal, but kind of skin-flinty.? I strongly identify with Jacques, FGA, and Donna Freedman in this respect.? Some of us never got into consumer debt and our only debt was student loans or mortgage debt if that.? We were gazelle intense before we ever heard of Dave Ramsey.

We have our own levels of personal finance.

This post is inspired by a recent article by Donna Freedman in which she?s contemplating how she needs more time in order to make more money without killing her health.? Doing every tiny thing from scratch is no longer worth her marginal wage.? Occasionally it?s worth more to her to *gasp* order a pizza.

So I present to you, the terrified-of-debt-ultra-responsible-perhaps-too-thrifty-by-US-standards levels of personal finance.

Levels:

1.? In this stage you?re just starting out.? If you have any debt (specifically:? education debt, car debt because you need transportation to work, emergency medical debt, or debt your ex-spouse left you) you?re scrambling to pay it off.? You don?t live beyond your means.? You eat a lot of rice and beans, or potatoes and onions and you know how much everything you ever buy costs.? You watch every penny and every wasted penny is mourned.? (And you beat yourself up over its loss.)

2.? In stage two, your debts are gone and you have a tiny emergency fund.? This allows you to feel comfortable adding a little meat and fruit and vegetable to your diet, even if these items aren?t scavenged from the ?odd ends? or ?eat today? section of your grocery.? You still keep close eyes on every penny.

3.? In this stage, you have a nice emergency fund and your income has gone up so you feel comfortable that an emergency isn?t going to kill you.? Additionally, you realize that your time is valuable because your real wage is pretty high.? Instead of saving $5 soaking beans, you could be making $25 working the same amount of time.? You start doing cost-benefit analyses, you realize you can outsource things you dislike (or that are just time-consuming) if the monetary trade-off is high enough.?? You spend nickels and dimes, but mindfully and optimally.

4.? In level four you have a really big emergency fund and your income is high enough compared to your spending that you could replenish your emergency fund in a month or two.? Say you?re saving 40-60% of your income and you?re not feeling particularly deprived doing so.? One day you suddenly realize that you can slip up and it?ll be just fine.? Rather than beating yourself up over a lost penny you say to yourself, ?it?s only money, and I?m still doing fine.?? You stop watching the pennies.? Instead you put away dollars and feel free to spend what is left.? It?s ok to mess up because the dollars are already saved.? At this stage you may even decide it isn?t worth your time to argue when a company mischarges you for something, but you probably will anyway, just out of the principle of the thing.? (Even if it?s not an optimal use of your time.)? You may do cost-benefit analysis from time to time, but sometimes you decide it is not worth your time to do so.? You?re a lot more relaxed about nickles and dimes so long as you?re keeping tabs on the dollars and hundreds and thousands.? A certain zen slips in.? You?re still frugal on the whole, but that frugality allows you to stop worrying so dang much.

In one of my favorite MSN articles not written by Donna Freedman, Liz Pulliam Weston talks about when you no longer need a formal budget.? Basically it?s when you?re out of debt and spend a lot less than you earn just naturally.? Your savings are on auto-pilot and an emergency isn?t going to wipe you out.? This happens in level 4.

Where?s Donna?? I can?t really say because it?s her income, her savings, and her comfort level that determines that.? But, based on her recent blog post (the one that inspired this one), it sounds like at level 3.? But (hopefully) at some point she?ll be able to look at her savings and at her regular income and realize she?s suddenly at her own level 4.? And that will be good for her blood pressure!? That level of peace is well worth the hard-effort that built up to it.

I?m not sure if level 4 was what I was aiming for back when I lost my ability to digest red meat back at level 1.? But having gotten to level 4, I never ever want to go back.? And that?s what keeps me saving a large portion of our income and keeps me wanting to earn more than we spend.? If necessary we could go back to level 3, but I?d really rather not.

Do these levels describe you, or are you more the standard, ?got into consumer debt and saw the light? or something more moderate entirely?? What level are you at?? When do you think you?ll be able to stop worrying so much?? Or do you maybe not worry enough?

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Source: http://nicoleandmaggie.wordpress.com/2011/12/26/yet-another-levels-of-personal-finance/

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Holland Taylor on life, love and Charlie Sheen (Reuters)

WASHINGTON (Reuters) ? Holland Taylor offers no apologies for never settling down, getting married or having children.

The 68-year-old Emmy-winning actress, currently starring in her one-woman show "Ann" at Washington D.C.'s Kennedy Center, simply never had the time.

"I always did think I would be married and settled down by now but maybe I ain't ready," she said, sounding a lot like the over-the-top mother of Jon Cryer she portrays in the CBS comedy "Two and a Half Men." "Then again, maybe I won't ever be ready."

Taylor's career blossomed in her mid-30s and the New Yorker with Pennsylvania roots has been on a dizzying pace ever since, starring on the stage, in television and on film.

Having a family just wasn't in the script.

"I'm very, very happy. I just never was the marrying kind," she said. "I am a serial monogamist. I don't have multiple relationships at once.

"I've had a long life and a lot of relationships and not one of them do I wish -- well, I take that back -- there are a couple I could have done without," she added with a chuckle.

Taylor's current love is "Ann," which is based on the life of quick-witted, sharp-tongued former Texas Gov. Ann Richards.

Seconds after a recent performance at the Kennedy Center, the audience was on its feet, cheering wildly for the show and its star.

While the applause was quick that night, overall it was a long time coming for Taylor. The actress conceived the show nearly six years ago and has been researching it and writing it ever since. She admits to being captivated about the dynamic Richards, who died in 2006 of esophageal cancer.

"I had a lot of creative feelings about her," Taylor told Reuters. "If I had been a painter, it would have been a painting. If I had been a composer, it would have been a piece of music. I had to do something with my feelings about this loss."

Taylor said the idea of taking Richards' story to the stage "came to me very suddenly."

"I was literally driving to work at my television show one day and I had to pull off the highway onto the service road," she recalled. "I had the idea it should be a play because of her liveliness and her contact with the audience.

"She herself said, 'I was good as a candidate over the years only because I connect with people one on one.' I decided right then a play is how it should be done."

NO LOOKING BACK

Taylor has perfected Richards' Southern drawl and eerily looks like the Texas politician whose energizing keynote address at the 1988 Democratic National Convention elevated her to widespread prominence.

The actress insists she brought Richards' story to the stage not because she could play the role but to celebrate the politician's life.

"She was not a person who looked back. Ever," Taylor said. "She did not revisit things. She was rolling along, like a wheel that goes under and then over. Under and over. But always moving forward.

"If she fell, she fell forward. And that is not the way I am. I get very upset. I can get very waylaid. I get blue. I can become chicken little.

"And now when I do, I think, 'What would Ann Richards think of this behavior?'"

During breaks in the show's pre-Broadway tour -- it is playing now through January 15 at the John F. Kennedy Center for the Performing Arts -- Taylor will continue her role on "Two and a Half Men." She is glad its former star, Charlie Sheen, survived his firing and public meltdown earlier this year and has moved on.

"It was painful for me to see him in pain and he did something very, very dangerous by first of all, obviously doing drugs to that degree is dangerous, but quitting very violently is very dangerous too," she said.

"And he went through really an amazing thing out in public. I just was terrified for him. I think everybody was. But he got through it alive which is all anybody wanted."

Taylor said she would see his daily rants and described them as "very scary."

"There were a few days there where I would open the paper, and I would be so frightened to see that something really terrible happened," she said. "I'm glad he escaped that."

Holland Taylor is in a good spot these days, healthy, happy and with more job offers than she knows what do with. Just don't expect her to slow down anytime soon.

With a laugh, she said she would "commit an ax murder" before attempting to conceal her age.

"It would seem so silly," she said backstage at the Kennedy Center. "I really, truly genuinely struggled quite hard until I was in my mid-30s. "I personally was at sea.

"But that's long gone. I'm doing OK. I'm better than OK."

(Editing by Bob Tourtellotte)

Source: http://us.rd.yahoo.com/dailynews/rss/celebrity/*http%3A//news.yahoo.com/s/nm/20111226/en_nm/us_hollandtaylor

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Dear President Obama, Free Oscar L?pez Rivera

Post to Twitter

He is entering his 30th year as a political prisoner in the United States, and even after he served another 10 years as a condition of a commuted sentence by President Bill Clinton, Puerto Rico's Oscar L?pez Rivera is still in jail.

It is time to free him. Please share, post, and let your friends know that L?pez Rivera should be free. For more information, visit this page. You can download a letter to ask for his release here.

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Source: http://latinorebels.com/2011/12/26/dear-president-obama-free-oscar-lopez-rivera/?utm_source=rss&utm_medium=rss&utm_campaign=dear-president-obama-free-oscar-lopez-rivera

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Monday, December 26, 2011

FBI shooting range is popular deer hangout

(AP) ? Call it a playground for Bambi and G-Men, where imaginary criminals are hunted and deer are the spectators.

The 547-acre FBI Academy, where some of the nation's best marksmen fire off more than 1 million bullets every month, happens to be one of the safest places for deer during hunting season.

The property on the Marine Corps base in Quantico, Va., is home to some of the FBI's most elite forces and training programs as well as a de facto wildlife refuge where deer, fox, wild turkeys, groundhogs and vultures roam fearless and free.

In recent years, a black bear was spotted running across a parking lot, and a groundhog cornered an FBI agent coming out of the cafeteria, hoping to score some human food, FBI spokesman Kurt Crawford said. Turkey vultures are often seen perched atop the 500,000-square-foot national crime lab where the FBI analyzes evidence, including the remains of the former al-Qaida leader in Iraq.

The wild animals are as much a fixture at the academy as the hostage rescue team and criminal profilers.

The most common furry friends on the sprawling campus some 30 miles outside Washington are the deer, a regular at the shooting ranges, driving courses and physical training trails.

On a December afternoon, deer grazed above one of the academy's 16 practice shooting ranges. They stood just 15 feet away from the paper targets. Nearby, shots popped loudly from a Colt M4 Carbine rifle, and the white-tailed deer did not flinch.

"They're pretty immune to the sound," said Sean Boyle, supervisory special agent bomb technician and principal firearms instructor for the Critical Incident Response Group based at the academy. The deer typically graze on top of the berm, about 15 feet away from the targets and rarely go directly in the line of fire. Boyle said he doesn't recall an instance where a deer was shot accidentally.

"It's like they think, 'We've pushed the limit for this far, and all our generations have pushed the limit for this far,'" Boyle said. "They're just so docile around here. They don't know what a gun is."

The Virginia Department of Game and Inland Fisheries does not keep direct tabs on the deer population at the FBI academy, but a spokeswoman said statewide the deer population has remained about the same over the past decade, partly because of regulated hunting. Licensed deer hunters are allowed on parts of the Marine Corps base but not at the academy where the FBI does not hunt its animals.

At the FBI Academy, the deer have even become part of the training in some of the driving courses, said Tim Moles, the supervisory special agent who oversees the Tactical and Emergency Vehicle Operations Center, where recruits learn to avoid crashing their cars and conduct surveillance without being spotted. The deer are convenient when recruits learn to avoid collisions, Moles said. "There's times when it seems like they're playing chicken with us," Moles said. "We respect them because they can do damage. We'd rather avoid all deer stories in this end of the academy."

For the most part, the deer have stayed out of trouble. Twice, however, deer have eaten freshly-planted pansies at the academy's 9/11 memorial courtyard, Crawford said. Eventually a fence was built to keep the flowers off limits.

Deer have been known to interrupt physical training, too.

"We've had the deer walk across the middle of the track during the 300-meter sprint," said Susann Dreiling, unit chief of the academy's physical training unit.

To become an agent, recruits must pass a physical fitness test. They are scored on how fast they can run and how many push-ups and sit-ups they perform. Sometimes, training will involve running a quarter-mile path along the lake area of the academy, stopping for push-ups, running some more and breaking to box, Dreiling said.

During these exercises, a mother and her fawns are often close by.

"They just stand there and watch as if they're evaluating them," Dreiling said, "just like the instructors are."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2011-12-26-FBI%20Academy-Deer/id-f1351187cfca46cf86f6b215eecb18aa

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UK's fairy shrimps under threat

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Source: http://www.labspaces.net/116315/UK_s_fairy_shrimps_under_threat

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Sunday, December 25, 2011

Oil rises to near $100 amid improving US economy (AP)

SINGAPORE ? Oil prices closed in on $100 a barrel Friday in Asia amid expectations an improving U.S. economy will boost demand for crude.

Benchmark crude for February delivery was up 23 cents to $99.76 a barrel at late afternoon Singapore time in electronic trading on the New York Mercantile Exchange. The contract rose 86 cents to finish at $99.53 on Thursday.

In London, Brent crude was down 4 cents at $107.85 on the ICE futures exchange.

Crude has jumped from below $93 earlier this week on evidence of a slow but steady improvement in the U.S. economy.

The number of people applying for unemployment benefits dropped last week to the lowest level since April 2008, the third week in a row that applications fell. The Conference Board reported that its measure of future economic activity jumped last month, the second straight gain.

"This is a market that just appears to want to go higher," energy consultant and trader The Schork Group said in a report. "All good positive economic headlines are hyped and all poor headlines are ignored. Bears seem unable to keep crude from finishing 2011 below $100."

The market is also primed for potential threats to global crude supplies, such as rising tensions between Iran and Western nations over Iran's nuclear power program. The U.S. and Europe may bolster sanctions against the world's fourth crude biggest producer.

"Iran might not passively wait for sanctions to be applied and could act unilaterally to embargo supplies," J.P Morgan said in a report. "We are also concerned about Iraq, where political uncertainties seem to be rising following the U.S. troop pullout."

"We expect Iraq to add about 500,000 barrels a day of new supply in both 2012 and 2013, and any deviation from its present course could have serious implications for global supply."

Trading volume is normally low during the next week as many traders take vacations around the Christmas and New Year's Day holidays. Global oil markets are closed Monday for Christmas.

In other energy trading on the Nymex, natural gas fell 3.3 cents to $3.14 per 1,000 cubic feet. Heating oil rose 0.4 cent to $2.92 a gallon and gasoline futures were up 0.4 cent to $2.64 a gallon.

Source: http://us.rd.yahoo.com/dailynews/rss/economy/*http%3A//news.yahoo.com/s/ap/20111223/ap_on_bi_ge/oil_prices

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Gingrich fails to qualify for Va. primary ballot (AP)

WASHINGTON ? Republican presidential hopeful Newt Gingrich failed to qualify for Virginia's Super Tuesday primary ballot, the latest setback for a candidate whose standing in polls has been slipping. Gingrich's campaign said he would pursue an aggressive write-in campaign, though state law prohibits write-ins on primary ballots.

The state party said early Saturday that Gingrich and Texas Gov. Rick Perry had failed to submit the required 10,000 signatures to appear on the March 6 ballot.

Failing to get on the ballot in Virginia, where Gingrich lives, underscores the difficulty first-time national candidates have in preparing for the long haul of a presidential campaign.

And it illustrates the advantage held by Mitt Romney, the former Massachusetts governor, who has essentially been running for president for five years. Romney's team, larger than those of most of his opponents, has paid close attention to filing requirements in each state. He will appear on the Virginia ballot along with Texas Rep. Ron Paul, who also has run a national campaign before.

Ironically, Gingrich had a slight lead over Romney in a Quinnipiac poll of Virginia Republicans released earlier in the week.

The former House speaker surged in popularity in early December and tried to use that momentum to make up for a stalled campaign organization. But his standing in polls has slipped in recent days amid a barrage of negative ads in Iowa, where the Jan. 3 caucuses begin the contest for the Republican presidential nomination.

Three other candidates ? Minnesota Rep. Michele Bachmann, former Pennsylvania Sen. Rick Santorum and former Utah Gov. Jon Huntsman ? did not submit signatures before Virginia's deadline of 5 p.m. Thursday.

Gingrich's campaign attacked Virginia's primary system on Saturday, saying that "only a failed system" would disqualify Gingrich and other candidates and vowing to run a write-in campaign.

"Voters deserve the right to vote for any top contender, especially leading candidates," Gingrich campaign director Michael Krull said in a statement. "We will work with the Republican Party of Virginia to pursue an aggressive write-in campaign to make sure that all the voters of Virginia are able to vote for the candidate of their choice."

However, according to state law, "No write-in shall be permitted on ballots in primary elections."

"Virginia code prohibits write-ins in primaries. He can't do it," said Carl Tobias, a law professor at University of Richmond.

Tobias said Gingrich may have had trouble meeting a requirement that he must submit 400 signatures from each of Virginia's 11 congressional districts.

Gingrich's campaign did not immediately respond to a request for comment. Gingrich had been concerned enough to deliver his signatures personally. Rushing Wednesday from New Hampshire, which holds its primary on Jan. 10, he had supporters sign petitions before entering a rally in Arlington, Va.

Virginia GOP spokesman Garren Shipley said in a statement that volunteers spent Friday validating signatures on petitions that Romney, Paul, Perry and Gingrich had submitted. "After verification, RPV has determined that Newt Gingrich did not submit required 10k signatures and has not qualified for the VA primary," the party announced early Saturday on its Twitter feed. Shipley did not respond to telephone calls Saturday seeking comment.

Forty-six delegates will be at stake in Virginia's Super Tuesday primary. That's a small fraction of the 1,144 delegates needed to win the nomination. But they could prove pivotal in a close race, especially for a candidate like Gingrich, who expects to do well in Southern contests.

Gingrich already missed the deadline to appear on the ballot in Missouri's Feb. 7 primary, though he insists it doesn't matter because the state awards delegates based not on the primary but on a Republican caucus held in March.

Meanwhile, Virginia's Democrats said President Barack Obama's re-election campaign gathered enough signatures to get him on the state's primary ballot though he was the only candidate who qualified.

___

Associated Press writers Will Lester and Stephen Ohlemacher contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20111224/ap_on_el_pr/us_gop_ballot

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dmc0603: RT @philliesgirrrl Hey girls, blow jobs are great last minute gift ideas!!

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Saturday, December 24, 2011

TheBradBlog: RT @GreenNewsReport 12/22 rpt: Chinese 'occupy' coal; Arctic 'methane bomb'; Nigeria oil spill; Victory for breathers! http://t.co/FOETzf8D

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Video: How's Apple Since Steve Jobs?

Since Apple has lost their iconic leader, Steve Jobs, how has the company fared? Sharing insight into Apples past, current and predicted future, with Alex Guana, JMP Securities, senior research analyst and James Brehm, Compass Intelligence, senior stra...

Source: http://video.msnbc.msn.com/cnbc/45769592/

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Friday, December 23, 2011

Exclusive: N.Korea military backs Kim heir but will share power (Reuters)

BEIJING (Reuters) ? North Korea's new young leader will have to share power with an uncle and the military after the death of his father Kim Jong-il as the isolated country shifts to collective rule from strongman dictatorship, a source with close ties to Pyongyang and Beijing said.

The source added that the military, which is trying to develop a nuclear arsenal, has pledged allegiance to the untested Kim Jong-un who takes over the family dynasty that has ruled North Korea since it was founded after world War Two.

The source also said Beijing was only notified of Kim's death earlier on Monday, the same day that North Korean state television broadcast the news. Kim died on Saturday.

The source declined to be identified but has correctly predicted events in the past, telling Reuters about the North's first nuclear test in 2006 before it took place.

The situation in North Korea appeared stable after the military gave its backing to Kim's son and successor, Kim Jong-un, the source said.

"It's very unlikely," the source said when asked about the possibility of a military coup. "The military has pledged allegiance to Kim Jong-un."

With no military strongman, North Korea will be ruled by collective leadership, including Kim Jong-un, his uncle and the military, the source said.

Jang Song-thaek, 65, brother-in-law of Kim Jong-il and the younger Kim's uncle, was named in 2009 to the National Defense Commission, the supreme leadership council Kim Jong-il led as head of the military state.

The source also said the North Korea test-fired a missile on Monday to warn the United States not to make any moves against it. Pyongyang also had no immediate plans for further tests barring an escalation of tensions.

"With the missile test, (North) Korea wanted to deliver the message that they have the ability to protect themselves," the source said.

"But (North) Korea is unlikely to conduct a nuclear test in the near future unless provoked" by the United States and South Korea, the source said.

The North's nuclear program has been a nagging source of tensions with the international community. Pyongyang carried out nuclear tests in 2006 and 2009, and has quit six-party talks with South Korea, the United States, China, Japan and Russia on abandoning its nuclear program and returning to the Non-Proliferation Treaty.

China, the North's closest ally and biggest provider of aid,

on Tuesday welcomed the new North Korean leader to visit after his father's death. Chinese President Hu Jintao and Vice-President Xi Jinping also visited the hermit state's embassy in Beijing to express their condolences on Tuesday. Roads leading to the embassy were blocked.

Still the prospect of instability on its northeastern border worries China. North Korea has been pressed by China to denuclearize and is willing to do so on condition that North and South Korea, the United States and China sign an armistice replacing a 1953 ceasefire agreement, the source said.

The two Koreas have been divided for decades and remain technically at war since their 1950 to 1953 conflict ended with an armistice but no peace agreement. The United States backed the South, while China supported the North in that conflict.

Pyongyang also is convinced there are U.S. nuclear weapons in South Korea and demands Washington pull them out, the source said.

Impoverished and squeezed by international sanctions for conducting its nuclear and missile tests, North Korea has increasingly turned to Beijing for help to fill the gap left by the drying up of economic assistance from South Korea and the United States.

(Editing by Brian Rhoads and Jonathan Thatcher)

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20111221/wl_nm/us_korea_north_exclusive

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Former Union Leader Admits Theft of Union Funds

??Former Union Leader Admits Theft of Union Funds

BUFFALO, NY?United States Attorney William J Hochul, Jr announced today that former union leader Ellis Woods, 61, of Clarence, NY ., pleaded guilty to wire fraud before United States District Judge Richard J Arcara. The charge carries a maximum penalty of 20 years in prison, a $250,000 fine or both.

Assistant United States Attorney Russell T Ippolito, Jr, who is handling the case, stated that the defendant devised a scheme to defraud the Buffalo Educational Support Team (?BEST?). BEST is a union representing more than 900 teacher?s aides and assistants in the Buffalo school district. While working as the elected President of BEST, Woods was provided a union issued credit card.

Between November 18, 2008, and February 7, 2011, Woods used the union credit card to pay for personal expenses, including gambling expenses that he incurred at local area casinos. In total, Woods stole $44,987.70 in union funds.

?Union members contribute hard earned money to benefit the union as a whole, not to line the pockets of union leaders,? said United States Attorney Hochul. ?Our office will not tolerate such behavior and will vigorously prosecute officials in any organization who seek to take advantage of members.?

The plea is the result of an investigation by the United States Department of Labor and the Federal Bureau of Investigation, under the direction of Christopher M Piehota.

Sentencing is scheduled for April, 19, 2012 at 1:00 PM in Buffalo, NY. before Judge Arcara.

Reported by: FBI

Published on: 2011-12-23

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New take on impacts of low dose radiation

Tuesday, December 20, 2011

Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab), through a combination of time-lapse live imaging and mathematical modeling of a special line of human breast cells, have found evidence to suggest that for low dose levels of ionizing radiation, cancer risks may not be directly proportional to dose. This contradicts the standard model for predicting biological damage from ionizing radiation - the linear-no-threshold hypothesis or LNT - which holds that risk is directly proportional to dose at all levels of irradiation.

"Our data show that at lower doses of ionizing radiation, DNA repair mechanisms work much better than at higher doses," says Mina Bissell, a world-renowned breast cancer researcher with Berkeley Lab's Life Sciences Division. "This non-linear DNA damage response casts doubt on the general assumption that any amount of ionizing radiation is harmful and additive."

Bissell was part of a study led by Sylvain Costes, a biophysicist also with Berkeley Lab's Life Sciences Division, in which DNA damage response to low dose radiation was characterized simultaneously across both time and dose levels. This was done by measuring the number of RIF, for "radiation induced foci," which are aggregations of proteins that repair double strand breaks, meaning the DNA double helix is completely severed.

"We hypothesize that contrary to what has long been thought, double strand breaks are not static entities but will rapidly cluster into preferred regions of the nucleus we call DNA repair centers as radiation exposure increases," says Costes. "As a result of this clustering, a single RIF may reflect a center where multiple double strand breaks are rejoined. Such multiple repair activity increases the risks of broken DNA strands being incorrectly rejoined and that can lead to cancer."

Costes and Bissell have published the results of their study in the Proceedings of the National Academy of Sciences in a paper titled "Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells." Also co-authoring the paper were Teresa Neumaier, Joel Swenson, Christopher Pham, Aris Polyzos, Alvin Lo, PoAn Yang, Jane Dyball, Aroumougame Asaithamby, David Chen and Stefan Thalhammer.

The authors believe their study to be the first to report the clustering of DNA double strand breaks and the formation of DNA repair centers in human cells. The movement of the double strand breaks across relatively large distances of up to two microns led to more intensely active but fewer RIF. For example, 15 RIF per gray (Gy) were observed after exposure to two Gy of radiation, compared to approximately 64 RIF/Gy after exposure to 0.1Gy. One Gy equals one joule of ionizing radiation energy absorbed per kilogram of human tissue. A typical mammogram exposes a patient to about 0.01Gy.

Corresponding author Costes says the DNA repair centers may be a logical product of evolution.

"Humans evolved in an environment with very low levels of ionizing radiation, which makes it unlikely that a cell would suffer more than one double strand break at any given time," he says. "A DNA repair center would seem to be an optimal way to deal with such sparse damage. It is like taking a broken car to a garage where all the equipment for repairs is available rather than to a random location with limited resources."

However, when cells are exposed to ionizing radiation doses large enough to cause multiple double strand breaks at once, DNA repair centers become overwhelmed and the number of incorrect rejoinings of double strand breaks increases.

"It is the same as when dozens of broken cars are brought to the same garage at once, the quality of repair is likely to suffer," Costes says.

The link between exposure to ionizing radiation and DNA damage that can give rise to cancerous cells is well-established. However, the standards for cancer risks have been based on data collected from survivors of the atomic bomb blasts in Japan during World War II. The LNT model was developed to extrapolate low dose cancer risk from high dose exposure because changes in cancer incidence following low dose irradiation are too small to be measurable. Extrapolation was done on a linear scale in accordance with certain assumptions and the laws of physics.

"Assuming that the human genome is a target of constant size, physics predicts DNA damage response will be proportional to dose leading to a linear scale," Costes explains. "Epidemiological data from the survivors of the atomic bombs was found to be in agreement with this hypothesis and showed that cancer incidence increases with an increase in ionizing radiation dose above 0.1 Gy. Below such dose, the picture is not clear."

Previous studies failed to detect the clustering of double break strands and the formation of DNA repair centers because they were based on single-time or single-dose measurements of RIF at a discrete time after the initial exposure to ionizing radiation. This yields a net number of RIF that does not account for RIF that have not yet appeared or RIF that have already made repairs and disappeared. The time-lapse imaging used by Costes, Bissell and their co-authors showed that RIF formation continues to occur well beyond the initial radiation exposure and after earlier repair issues have been resolved. Time-lapse imaging also indicates that double strand break clustering takes place before any RIF are formed.

"We hypothesize that double strand break clustering occurs rapidly after exposure to ionizing radiation and that RIF formation reflects the repair machinery put in place around a single cluster of double strand breaks," Costes says. "Our results provide a more accurate model of RIF dose response, and underscore fundamental concerns about static image data analysis in the dynamic environment of the living cell."

Previous studies also mostly involved fibroblast cells whereas Costes, Bissell and their colleagues examined epithelial cells, specifically an immortalized human breast cell line known as MCF10A, which has a much higher background of RIF than fibroblasts, even without ionizing irradiation. To compensate for this higher background, Costes developed a mathematical method that enables background to be corrected for on a per- nucleus basis in unirradiated cells. Still the use of a special line of immortalized breast cells is an issue that Costes and his colleagues plan to address.

"We are now looking at primary breast epithelial cells that have been removed from healthy donors to determine if our results are repeated beyond just a single cell line and under more realistic physiological conditions," Costes says. "We'd also like to know if our findings hold true for fibroblasts as well as epithelial cells. Also, we'd like to know if double strand break clustering is the result of a random coalescence or if there is an active transport mechanism that moves these double strand breaks towards pre-existing DNA repair centers."

Working in collaboration with Rafael Gomez-Sjoberg of Berkeley Lab's Engineering Division, Costes and his group are also developing a special microfluidics lab-on-a-chip device that is integrated into an X-ray microbeam. The goal is to provide a means by which cells can be kept in a controlled microenvironment while being irradiated with multiple doses. This microfluidic array will be used to characterize DNA damage response in breast and blood cells collected from human donors.

"By characterizing DNA damage response in cells from many different human donors," Costes says, "we should be able to determine the variation across humans and gain a better understanding of how sensitivity to DNA damage from ionizing radiation might vary from individual to individual."

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DOE/Lawrence Berkeley National Laboratory: http://www.lbl.gov

Thanks to DOE/Lawrence Berkeley National Laboratory for this article.

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